The impact of diabetes mellitus on carotid atherosclerosis and arterial stiffness; results from the Corinthia study

Abstract Background Evaluation of arterial stiffness and carotid atherosclerotic burden can provide important prognostic information regarding the risk for future cardiovascular events. In that context, we tried to determine those vascular properties diabetic individuals compared non-diabetics. Methods this analysis observational “Corinthia” study, included 1757 participants with determined status. Propensity scores were employed match diabetics non-diabetics regards known factors. Carotid ultrasonography was performed evaluate intima-media thickness (cIMT) across common arteries bulbs as well plaque burden. Arterial estimated via assessment carotid-to-femoral pulse wave velocity (cfPWV). Results Diabetic had increased mean cIMT (diabetics: 1.12±0.50mm vs. 0.94±0.38mm, p<0.001) maximum 1.50±0.93mm 1.20±0.71mm, when (Figure 1, Panel A B). also in (34.4% 19.4% non-diabetics, while bilateral plaques observed 14.2% opposed 8.2% (p<0.001). Concerning stiffness, DM significantly higher values cfPWV (10.6±3.4m/s 8.8±2.5m/s C). propensity-matched cohort, 1.13±0.51mm 0.98±0.38mm, 1.53±0.95mm 1.24±0.73mm, 2, B), (36.6% 21.9% p<0.001). Analysis according territory measurement displayed substantial differences left 1.30±0.76mm non-diabetics: 1.06±0.58mm, right 1.30±0.82mm 1.07±0.57mm, respect C) but, unexpectedly, non-significant variations 0.97±0.48mm 0.90±0.42mm, p=0.06) artery 0.95±0.50mm 0.90±0.40mm, p=0.21) D). Conclusion We diabetes mellitus. As lesions more pronounced bulb not artery. Our findings may raise awareness focus echocardiographic examination subjects mellitus impact glucose-lowering therapies on these specific merits further assessment. FUNDunding Acknowledgement Type funding sources: None. Figure 1 2